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相文佩
来源:计划生育研究所     日期:2016-09-01     浏览数:     【 字体:

相文佩    医学博士,教授,博士生/硕士生导师。

学术经历 2005年毕业于华中科技大学同济医学院,获得妇产科学博士学位;2011年至2013年在美国匹兹堡大学医学中心做访问学者。

社会兼职:中华医学会生殖医学分会青年委员,中华医学会计划生育分会青年 委员,湖北省医学会生殖医学分会委员,湖北省性学会理事。国家自然基金评审专家。

学术成果:主持过国家自然科学基金项目2项;在国内外学术期刊发表论著四十余篇,其中SCI收录论文13篇。参编国家“十一五”规划教材《生殖疾病学》、《临床生殖医学》、《女性不育症》。

 研究方向:

1)卵巢早衰发病机制的研究;生殖衰老的表观遗传学及环境因素的研究。

2)卵子发生研究:线粒体融合基因在卵子减数分裂过程中调控作用及机制研究。

3)干细胞研究:成体干细胞在卵巢早衰及自然生殖衰老中的修复作用及机制探索。

主持项目:

1. 20162019:国家自然基金面上项目,BMSCs调控ERRα/Mfn2/ 线粒体途径改善老龄化卵泡发育和质量的探索性研究, (项目批准号:81571434)。

2.  2013.1-2015.12,国家自然基金青年项目,线粒体融合蛋白Mfn2 调控线粒体功能对卵母细胞成熟和质量的影响, (项目批准号:31201079)。 

3. 主持省市级课题多项。

代表论文和著作:(#通讯作者,*第一或者并列第一作者)

1. Liu Q, Kang L, Wang L, Zhang L, Xiang W#. Mitofusin 2 regulates the oocytes development and quality by modulating meiosis and mitochondrial function. Sci Rep. 2016 Jul 29; 6:30561. 

2. Zhang L*, Xiang W*, Wang G, Yan Z, Zhu Z, Guo Z, Sengupta R, Chen AF, Loughran PA, Lu B, Wang Q, Billiar TR. Interferon β (IFN-β) Production during the Double-stranded RNA (dsRNA) Response in Hepatocytes Involves Coordinated and Feedforward Signaling through Toll-like Receptor 3 (TLR3), RNA-dependent Protein Kinase (PKR), Inducible Nitric Oxide Synthase (iNOS), and Src Protein. J Biol Chem. 2016 Jul 15; 291(29): 15093-107.

3. Wang L, Xu X, Kang L, Xiang W#. Bone Marrow Mesenchymal Stem Cells Attenuate Mitochondria Damage Induced by Hypoxia in Mouse Trophoblasts. PLoS One. 2016 Apr 21; 11(4): e0153729.

4. Chen W, Xu X, Wang L, Bai G, Xiang W#. Low Expression of Mfn2 Is Associated with Mitochondrial Damage and Apoptosis of Ovarian Tissues in the Premature Ovarian Failure Model. PLoS One. 2015 Sep 1; 10(9): e0136421.

5. Zhao N, Zhang Y, Liu Q, Xiang W#. Mfn2 Affects Embryo Development via Mitochondrial Dysfunction and Apoptosis. Plos one. 2015 May 15; 10(5): e0125680.

6. Pang WJ, Zhang Y, Zhao N, Darwiche SS, Fu XC, Xiang WP#. Low expression of Mfn2 is associated with mitochondrial damage and apoptosis in the placental villi of early unexplained miscarriage. Placenta. 2013 Jul; 34(7): 613-8.

7. Xu XY, Pang WJ, Wen ZN, Xiang WP#. Changes in human umbilical vein   endothelial cells induced by endothelial nitric oxide synthase traffic inducer. J Huazhong Univ Sci Technolog Med Sci. 2013 Apr; 33(2): 272-6.

8. Bhattacharjee R, Xiang WP*, Wang Y, Zhang X, Billiar TR. cAMP prevents TNF-induced apoptosis through inhibiting DISC complex formation in rat hepatocytes. Biochem Biophys Res Commun. 2012 Jun 22; 423(1): 85-90.

9. Zhang Y, Jiang L, Hu W, Zheng Q, Xiang WP#. Mitochondrial dysfunction during in vitro hepatocyte steatosis is reversed by omega-3 fatty acid-induced up-regulation of mitofusin 2. Metabolism. 2011, 60(6): 767-75.

10.  Xiang WP*Wen ZN,Pang WJ,Hu L,  Xiong CL,  Zhang Y. CR16 forms a complex with N-WASP in the human testes. Cell Tissue Res. 2011, 344(3): 519-26.

11.  Chen QJ, Xiang WP*, Zhang DK, Wang RP, Luo YF, Kang JZ, Cheng LN. Efficacy and safety of a levonorgestrel enteric-coated tablet as an over-the-counter drug for emergency contraception: a Phase IV clinical trial. Hum Reprod. 2011 Sep; 26(9): 2316-21.

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