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教授
廖爱华
来源:计划生育研究所     日期:2017-06-20     浏览数:     【 字体:

D70F廖爱华 医学博士,教授,博士生/硕士生导师。现任华中科技大学同济医学院计划生育研究所所长。

社会兼职国际和美洲生殖免疫学会会员,中国免疫学会会员,中华医学会计生分会生殖保健学组副组长、湖北省性学会理事会理事/副秘书长、湖北省医学会生殖医学分会和计生分会委员CFDA药品审评中心专家国家自然科学基金评审专家

学术经历2003.52005.2 赴德国杜伊斯堡-埃森大学医学院免疫研究所研修学习,获医学博士学位(免疫学)。2003.92006.6在华中科技大学同济医学院攻读博士学位,获医学博士学位(妇产科学)。2012.82012.11赴美国罗莎琳德-富兰克林医科大学微生物和免疫系、妇产科系生殖医学中心访问交流(访问学者)。长期从事生殖医学科研、教学及临床(辅助生殖技术)工作。

学术成果:主持国家自然科学基金面上项目4项(在研2项)在国内外重要学术期刊发表第一或通讯作者中、英文论著及述评类文章十余篇,其中SCI收录20篇。并多次在国际、国内重要学术会议上进行学术报告。主编和参编国家“十一五”规划教材3部(《生殖疾病学》、《生殖药理学》和《女性不育症》)。

研究方向

1. 生殖免疫学方向:主要从事妊娠(如正常母-胎免疫耐受建立与维持)及妊娠相关性疾病(如子痫前期、复发性流产和IVF反复着床失败)的免疫学和代谢免疫学机制及其防治策略研究(如Treg/Th17平衡、巨噬细胞极化、PD-1/PD-L1Tim-3/Gal-9信号通路、维生素 D的免疫调节等);以及PD-/PD-L1信号通路与睾丸豁免机制研究

2.  生殖生物学研究方向(主要研究胚胎着床的机制)

主持项目:

1. 20172020:国家自然科学基金面上项目PD-1/Tim-3信号分子调控蜕膜巨噬细胞极化参与子痫前期发病的机制研究”(NO.81671490

2. 20162018年:默克雪兰诺中国生殖医学研究基金项目“维生素D补充疗法在反复着床失败中的临床应用及机制研究”NO. 0231519043

3. 20152018:国家自然科学基金面上项目PD-1/PD-L1信号通路调控Treg/Th17平衡在子痫前期发病机制中的研究”(NO.81471475

4. 20112013:国家自然科学基金面上项目Treg细胞调节B细胞在子痫前期发生中的作用和机制研究”(NO.81070507

5. 20062008:国家自然科学基金面上项目“人类记忆B细胞产生HLA抗体ELISpot标识体系的构建”(NO.30571710

代表论文和著作:

1. Zhang YH, He M, Wang Y, Liao AH*. Modulators of the Balance between M1 and M2 Macrophages during Pregnancy. Front Immunol, 2017; 8:120.

2. Liu ZZ, Sun GQ, Hu XH, Kwak-Kim J, Liao AH*. The transdifferentiation of regulatory T and Th17 cells in autoimmune/inflammatory diseases and its potential implications in pregnancy complications. Am J Reprod Immunol, 2017; e12657.

3. Hu XH, Tang MX, Mor G, Liao AH*. Tim-3: Expression on immune cells and roles at the maternal-fetal interface. J Reprod Immunol, 2016;118:92-99.

4. Tian M, Zhang Y, Liu Z, Sun G, Mor G, Liao A*. The PD-1/PD-L1 inhibitory pathway is altered in pre-eclampsia and regulates T cell responses in pre-eclamptic rats. Sci Rep, 2016;6:27683.

5. Huang D, Song S, Liao A*. Short-term safety evaluation of the offspring conceived by 7272 artificial insemination cycles with donor spermatozoon. Andrologia, 2016;48(7):817-23.

6. Tang MX, Hu XH, Liu ZZ, Kwak-Kim J, Liao AH*. What are the roles of macrophages and monocytes in human pregnancy? J Reprod Immunol, 2015; 112:73-80.

7. Zhang XH, Liu ZZ, Tang MX, Zhang YH, Hu Lian, Liao AH*. Morphological Changes and Cytokine Expression after Local Endometrial Injury in a Mouse Model. Reprod SCI, 2015;22(11):1377-86.

8. Tang MX, Zhang YH, Hu Lian, Kwak-Kim J, Liao AH*. CD14++CD16+HLA-DR+ Monocytes in Peripheral Blood are Quantitatively Correlated with the Severity of Pre-eclampsia. Am J Reprod Immunol, 2015;74(2):116-22.

9. Zhang YH, Tian M, Tang MX, Liu ZZ, Liao AH*. Recent Insight into the Role of the PD-1/PD-L1 Pathway in Feto–Maternal Tolerance and Pregnancy. Am J Reprod Immunol, 2015;74(3):201-8.

10. Zhang Y, Kwak-Kim J, Huang D, Hu L, Liao A*. Cyclic Changes and Relationship between Peripheral and Endometrial NK Cells from Women with Repeated Failure after Artificial Insemination by Donor Sperm. Am J Reprod Immunol, 2014;71(1):44-54.

11. Zeng B, Kwak-Kim J, Liu Y, Liao AH*. Treg Cells Are Negatively Correlated with Increased Memory B Cells in Pre-eclampsia While Maintaining Suppressive Function on Autologous B-Cell Proliferation. Am J Reprod Immunol. 2013;70(6):454-63.

12. Lu Y, Zhang F, Zhang Y, Zeng B, Hu L, Liao A*. Quantitative reduction of peripheral CD4+CD25+FOXP3+ regulatory T cells in reproductive failure after artificial insemination by donor sperm. Am J Reprod Immunol. 2013;69(2):188-193.

13. Kwak-Kim J*, Agcaoili MS, Aleta L, Liao A, Ota K, Dambaeva S, Beaman K, Kim JW, Gilman-Sachs A. Management of women with recurrent pregnancy losses and antiphospholipid antibody syndrome. Am J Reprod Immunol, 2013;69(6):596-607.

14. Hu L, Liao AH*, Song S, Xiao N, Xiang WP, Xiong CL. Evaluation of donor semen quality provided by six sperm banks: a retrospective study of 1877 artificial insemination cycles. Andrologia, 2012;44 Suppl 1:499-504.

15. Lu Y, Zeng B, Zhang Y, Xiang W, Hu L, Liao A*. Quantitative and functional changes in peripheral natural killer cells in women with reproductive failure after artificial insemination with donor sperm. J Reprod Immunol, 2011, 91(1-2): 83-9.

16. Liu LP, Huang W, Lu YC, Liao AH*. Enhanced maternal anti-fetal immunity contributes to the severity of hypertensive disorder complicating pregnancyAm J Reprod Immunol, 2010, 63(5): 379 ~ 386.

17. Liao AH*, Liu LP, Ding WP, Zhang L. Functional changes of human peripheral B-lymphocytes in pre-eclampsia. Am J Reprod Immunol, 2009, 61(5):313-21.

18. Li HG, Huang SY, Zhou H, Liao AH*, Xiong CL.Quick recovery and characterization of cell-free DNA in seminal plasma of normozoospermia and azoospermia: implications for non-invasive genetic utilities.Asian J Androl2009;11(6):703-9.

19. Zhang LWang YLiao AH*. Quantitative abnormalities of fetal trophoblast cells in maternal circulation in preeclampsia. Prenat Diagn, 2008, 28(12): 1160-1166.

20. Liao A*, Pang X, Li H, Xiong Z, Wu X. Bioavailability of mifepristone in capsule versus tablet form in healthy nonpregnant women. Contraception, 2008, 77(6): 431-434.

21. 廖爱华主编,《女性不育症》,2012 北京:人民卫生出版社.

22. 熊承良刘继红廖爱华主编.《生殖疾病学》,2007 福建:福建科学技术出版社

招收硕士生、博士生和博士后;联系邮箱:aihua_liao@sina.com

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