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客座教授
虞京葳
来源:计划生育研究所     日期:2017-03-22     浏览数:     【 字体:

虞京葳,男,1982年毕业于同济医学院生物医学师资班,毕业后就职于同济医学院医学遗传研究室,1987年获同济医学院医学遗传学硕士学位。1988年赴美留学,获科罗拉多大学生物物理学及遗传学博士学位,后赴耶鲁大学接受医学遗传学训练,并获得美国医学遗传学临床资质,分别在科罗拉多大学医学院、威斯康星大学麦迪逊分校医学院任教职。现任美国加州大学旧金山分校实验医学系教授,细胞遗传实验室主任。主要研究方向为肿瘤和染色体疾病的基因组学和表观遗传学分析及将染色体和分子标志物用于相关疾病临床诊断的研究。

 

代表论文:

[1] Huang V, Zheng J, Qi Z, Wang J, Place RF, Yu J, Li H, Li LC. Ago1 Interacts with RNA polymerase II and binds to the promoters of actively transcribed genes in human cancer cells. PLoS Genet, 2013, 9(9):e1003821.

[2]Ye L, Muench MO, Fusaki N, Beyer AI, Wang J, Qi Z, Yu J, Kan YW. Blood cell-derived induced pluripotent stem cells free of reprogramming factors generated by Sendai viral vectors. Stem Cells Transl Med, 2013, 2(8):558-566.

[3]Qin H, Blaschke K, Wei G, Ohi Y, Blouin L, Qi Z, Yu J, Yeh RF, Hebrok M, Ramalho-Santos M. Genomic and epigenetic analysis of cancer and chromosome disorders, development of chromosomal and molecular markers for clinical diagnosis.Hum Mol Genet, 2012, 21(9):2054-2067.

[4]Huang V, Place RF, Portnoy V, Wang J, Qi Z, Jia Z, Yu A, Shuman M, Yu J, Li LC. Upregulation of Cyclin B1 by miRNA and its implications in cancer,Nucleic Acids Res, 2012, 40(4):1695-1707.

[5] Lu CM, Zhou L, Feng S, Kohn PH, Qi Z, Yu J. Presence of complex t(6;9;22;15) four-way chromosome rearrangements plus a rare t(1;6) translocation does not affect the response to imatinib therapy in chronic myelogenous leukemia. Leukemia and Lymphoma, 2011, 52(11):2182-2184.

[6] Ohi Y, Qin H, Hong C, Qi Z, Blouin L, Polo J, Guo T, Downey S, Hebrok M, Hochedlinger K, Yu J, Costello J, Song JS, Ramalho-Santos M. Incomplete DNA methylation underlies a transcriptional memory of the somatic cell in human iPS cells. Nat Cell Biol, 2011, 13(5):541-549.

[7] Ye L, Chang JC, Lin C, Qi Z, Yu J, Kan YW. Generation of induced pluripotent stem cells using site-specific integration with phage integrase. Proc Natl Acad Sci U S A, 2010, 107(45):19467-19472.

[8] Ye L, Chang JC, Lin C, Sun X, Yu J, Kan YW. Induced pluripotent stem cells offer new approach to therapy in thalassemia and sickle cell anemia and option in prenatal diagnosis in genetic diseases. Proc Natl Acad Sci U S A, 2009, 106(24):9826-9830.

[9] Yu J, Zhang Y, Qi Z, Kurtycz D, Vacano G, Patterson D. Methylation-mediated downregulation of the B-cell translocation gene 3 (BTG3) in breast cancer cells. Gene Expr, 2008, 14(3):173-182.

 

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